Hi Cybernetic,
I'm not clear what you're asking.
Inkscape can use all sorts of unit measurements, including feet and inches. But I'm not familiar with Sketchup, so not sure if that's what you mean. I think probably most people use Inkscape for art, but Inkscape can do some quite techical work. Although maybe not like drafting -- is that what you mean?
Yes, Inkscape can draw a 3' x 6' door. However, large drawings can slow Inkscape to a crawl (large in file size not necessarily in dimension)
...because thats not how isometric building are drawn...
What's not how isometric buildings are drawn??