I like doing maps in isometric (axonometric) perspective in inkscape, you know like the view used in various elder games such as a big part of the Tycoon games, AoE... and the like. This maps are just fantasy and aren't really meant to be produced in some way...
Anyway, more to the point I sometimes make annotations in a different layer (jot down positions and markins like: "player should start here"). I mostly do it with a contrasting color than the background, to make sure I see them when I activate the layer.
The PROBLEM: It's no big deal changing colors everytime so they don't mix with the background, but it would be a nice thing if there was a way to make a filter or a color button that said negative.
and everywhere the ink would be it would show the complementary color for that pixel example:
0xFF0000, 0xFF8000, 0xFFFF00 would look like 0x00FFFF, 0x007FFF, 0x0000FF
So the calculation would be 0x1000000 - color, or better 0xFFFFFF XOR color.
It would really be cool in my opinion
