Is anyone else having problems with .46 Inkscape on Windows Vista? Everytime I try to adjust the fill/stroke color the program closes with an internal error. Is there a way to get around this?

I don't have that problem. I'm using Vista 64. You might want to try re-installing it.

I've gotten it to work when I click the stroke/fill on the bottom, the problem is limited to inkscape preferences. Thanks.

The problem with Inkscape Preferences is a known bug (bug 236435). It's not a problem with Vista, as it also occurs under Windows XP, Windows 2000, OS X and Linux.