I spent an hour or so today playing around in Ink, basically running it through the gears and trying to learn what it can & can't do compared to Draw 12. Sometime, in the next week or two, I'll breakout the crayons and write my wish-list to the elves in Inkscape's R&D department.

For me the ability to customize a programs settings is a necessity. The ability to make custom two or three-key shortcuts are good, but custom macros are even better. One of GIMPs greatest features, for example, is how simple it is to bind macros to any thing listed in the menus. (MIDI learn, anyone?) So if you want to make a "screenshot" macro, you simply go to FILE, AQUIRE, SCREENSHOT and let your pointer hover on the SCREENSHOT command. Now press the keys you want to represent that command, I chose SHIFT CTRL ALT S, for example) and it automatically binds to those keys.
Sometimes working smarter trumps working harder.