Well, I can't find any existing bug report, although there's a chance one exists and I just don't understand certain technical language.
I would suggest filing a new bug report
https://launchpad.net/inkscape. Then you can communicate directly with developers (who hardly ever visit forums). Info about making a bug report, if you need it:
https://inkscape.org/en/contribute/report-bugs/And meanwhile, I wonder if there might be some other workflow, where this problem could simply be sidestepped? I've never used Matlab, and don't even know what it is. But I have to wonder if there might be some other options, somewhere along the line?
What if you imported the PNG into Inkscape, rather than in Matlab? I have no idea if that would help. But what I'm thinking is that the PNG would only have to be saved once.
Sorry, I wish I could be more helpful.