Welcome Sarah!
Which version of Inkscape was installed, when you upgraded your operating system?
When I open that link, it shows me 3 options (4.0.0, 4.1.0 and 4.1.1) which I'm guessing are options for Windows, since they don't have any clues related to operating system.
But I wonder if different Inkscape versions might need different versions of this python app?? Which versions does it offer you, and which one did you choose?
Edit - I'm not a Mac user, so I'm not very well informed about this. So just to clarify, I can only guess. Hopefully others will post soon.