Without having an example, I would say don't use the spiro spline itself. After you make the spriro spline path, use Path menu > Object to Path.
My guess would be using a "live" spiro spline is causing the problem. If you've played around with spiro spline very much, you may have noticed there are certain times when the path sort of goes berserk, and draws hundreds of coils and scribbles, sometimes many times larger than the page. I've had a single spiro spline path freeze Inkscape before!
If you haven't seen that, you can try it. Just make a spiro spline path with 5 or 6 nodes, open or closed. Then switch to the Node tool, and drag some of the nodes around. Usually for me, it's when they get close together when they turn to scribbles. But you could also make it happen by just flipping a spiro spline path, or rotating it, or sometimes just moving it around the canvas.
(It's a bug. But I've actually made the bug happen on purpose sometimes. Kind of like a child seeing shapes in a cloud, I'll see something in the scribble, and then convert it to a path, and start to edit, to emphasize whatever I saw there. Or sometimes I just like the design, and make into an abstract image.)